The Cytoprotective Effect of Amifostine Against Radiation Induced Toxicity
نویسندگان
چکیده
Radiation treatment is an important therapeutic option for a number of malignancies (American Cancer Society), but its use is frequently limited by adverse effects on normal tissues (Stone et al., 2003). Thus, the goal of most oncology treatments is to maximize the antineoplastic effect while minimizing deleterious outcomes for the patient. WR-2721 was developed by the U.S. Army Anti-Radiation Drug Development Program for its potential to protect against damage caused by ionizing radiation (Yuhas &Stoner, 1969). Today, WR2721 is known as amifostine (Ethyol®; MedImmune Oncology, Inc., Gaithersburg, MD). Initial preclinical studies demonstrated that amifostine could protect treated mice from lethal doses of radiation, and this protection did not extend to transplanted mammary tumor cells (Yuhas &Stoner, 1969).
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